The Challenge: The immediate goal of HIV vaccine research is to design candidate vaccines that cause the immune system to produce protective responses from both of its major armscellular immunity and neutralizing antibodies.
There are major challenges to discovering vaccines capable of eliciting both types of responses. While researchers have developed vaccine candidates capable of eliciting cellular immunity against HIV in animal studies, early data from clinical trials suggest that the responses in humans may not be sufficiently potent, and current candidate vaccines may be duplicative. In addition, while researchers have identified antibodies that can bind to and neutralize HIV, they have been unsuccessful in designing vaccine candidates to elicit those antibody responses.
“ We believe the time is right for the major scientific and other stakeholdersboth public and private sector, in developed and developing countriesto come together in a more organized fashion. ”
Statement of G8 industrialized countries on the Global HIV Vaccine Enterprise, 2004
Recommendations: The scientific plan makes the following recommendations for overcoming these obstacles:
|About the Enterprise||Scientific Strategic Plan||Get Involved||News & Events||AIDS Vaccine 2007 Conference|